Urea-Stibol in the Treatment of Kala-Azar
نویسندگان
چکیده
" stibacetin," which was the first aromatic compound of antimony to be used in the treatment of leishmaniasis, many aromatic compounds of antimony have been introduced. Von Heyden also introduced sodium meta-chloro-para-acetylamino stibinate, known as No. 471 or " stibosan," and an amine salt of p-amino-phenyl-stibinic acid known as No. 693 iboth of which proved to be very effective in the treatment of kala-azar. In this country Brahmachari prepared a carbamide derivative of p-amino-phenyl-stibinic acid and called it " urea-stibamine " and the Union Drug Co., of Calcutta prepared the same compound and put it on the market under the name of "stiburea."
منابع مشابه
On the Toxicity of Some Organic Antimonial Drugs Used for the Treatment of Kala-Azar
are widespread. Some indication of the value of antimony is the fact that without treatment the death rate from kala-azar is over 90 per cent, whereas with treatment in Indian kalaazar it is reduced to below 10 per cent. Although tartar emetic was found of value in the treatment of kala-azar, its considerable toxic effects made it imperative to obtain other derivatives which should be better to...
متن کاملObservations on the Antimony (Urea-Stibamine) Test for Kala-Azar
In the Indian Medical Gazette for June 1927, Chopra, Gupta, and David described a new serum test for kala-azar. These workers observed that when certain organic compounds of antimony were brought in contact with the serum from kala-azar patients in a miniature testtube, a thick flocculent precipitate was formed at the junction of the two; whereas with nonkala-azar sera no such precipitation occ...
متن کاملThe Treatment of Kala-Azar with Sodium Antimony-V-Gluconate: Preliminary Observations *The work reported in this paper was undertaken under the Endowment Fund of the Calcutta School of Tropical Medicine, aided by a grant from the Indian Research Fund Association.
A pentavalent antimony compound (Sdt. 561, solustibosan, antimony-v-hexonate, containing 20 mg. of antimony per c.cm. of solution) , that made a stable solution and could be given intramuscularly, was first introduced b) Prof. H. Schmidt, the pioneer worker on pent*1' valent antimony compounds. Kikuth and Schmidt (1938) found that this compound possessed a marked curative action in the le*,' ma...
متن کاملبیماریابی کالا آزار با استفاده از روش آگلوتیناسیون مستقیم
Visceral leishmaniasis (VL) has been found as an endemic disease in some areas in northwest and south parts of Iran during recent two decades. The species of the Leishmania has been characterized as L.infantum and the main sources of human infection in the endemic areas is dog. The majority of kala-azar cases are found among children in the age group of 1-4 years. As the delay in diagnosis and ...
متن کاملObservations on the Treatment of 25 Cases of Kala-Azar with Stibatin (Sodium Antimony Gluconate) *Being a paper read at the Annual General Meeting of the Surma Valley and Chittagong Division of the British Medical Association held at the Lungla Club on 26th January, 1946. †The paper condensed by the editor.
severe toxic reactions and, as such, small children, corpulent subjects and patients suffering from general anasarca, not an uncommon condition associated with kala-azar, could not be treated with urea stibamine. At the Annual General Meeting of the Assam and Northern Bengal Branch of the British Medical Association that was held in Shillong in November 1943, Shortt read an interesting paper de...
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